Medical code of metastic breast cancer

Contrary to the situation in early breast cancer, little is known about the prognostic relevance of the hormone receptor HR and human epidermal growth factor receptor 2 HER2 in metastatic breast cancer. The objectives of this study were to present survival estimates and to determine the prognostic impact of breast cancer subtypes based on HR and HER2 status in a recent cohort of metastatic breast cancer patients, which is representative of current clinical practice. Patients diagnosed with metastatic breast cancer between and were included. Information regarding patient and tumor characteristics and treatment was collected. Survival was estimated using the Kaplan-Meier method.

January 18, Researchers at the University of Adelaide have found new evidence about the positive role of androgens in breast cancer treatment with immediate implications for women with estrogen receptor-driven metastatic disease. Published today in Nature Medicine , the international study conducted in collaboration with the Garvan Institute of Medical Research, looked at the role of androgens—commonly thought of as male sex hormones but also found at lower levels in women—as a potential treatment for estrogen receptor positive breast cancer. In normal breast development, estrogen stimulates and androgen inhibits growth at puberty and throughout adult life. Abnormal estrogen activity is responsible for the majority of breast cancers, but the role of androgen activity in this disease has been controversial. Androgens were historically used to treat breast cancer, but knowledge of hormone receptors in breast tissue was rudimentary at the time and the treatment's efficacy misunderstood.

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